Reaction: Acalabrutinib to 1 product

Reaction
Acalabrutinib
DB11703
    Acalabrutinib M5 Metabolite (ACP-5530)
    DBMET02885
    Reaction type
    glutathione conjugation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Podoll T, Pearson PG, Evarts J, Ingallinera T, Bibikova E, Sun H, Gohdes M, Cardinal K, Sanghvi M, Slatter JG: Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans. Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459. Epub 2018 Nov 15. [Article]
    Comments
    Not Available
    Enzymes
    Not Available