Amiloride hydrochlorideProduct ingredient for Amiloride

Show full entry for Amiloride
Name
Amiloride hydrochloride
Drug Entry
Amiloride

A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

See full entry for Amiloride
Accession Number
DBSALT001807
Structure
Similar Structures
Synonyms
Amiloride chloride / Amiloride HCl / Amiloride hydrochloride anhydrous / Amiloride Hydrochloride, Anhydrous / Amiloride monohydrochloride / N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride
UNII
7M458Q65S3
CAS Number
2016-88-8
Weight
Average: 266.09
Monoisotopic: 265.0245633
Chemical Formula
C6H9Cl2N7O
InChI Key
ACHKKGDWZVCSNH-UHFFFAOYSA-N
InChI
InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
IUPAC Name
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
SMILES
Cl.NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N
ChemSpider
15402
ChEBI
84743
ChEMBL
CHEMBL540851
Wikipedia
Amiloride
Predicted Properties
PropertyValueSource
Water Solubility0.616 mg/mLALOGPS
logP-0.48ALOGPS
logP-0.5Chemaxon
logS-2.6ALOGPS
pKa (Strongest Acidic)11.43Chemaxon
pKa (Strongest Basic)7.35Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count5Chemaxon
Polar Surface Area156.79 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity67.18 m3·mol-1Chemaxon
Polarizability20.01 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon