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Add-On

Clinical Trials & Rare Diseases

This package has 3 modules. The Clinical Trials Module has 15 tables. Preview the first five rows of each table or Explore the schema

Clinical Trials Module

15 Tables

Provides detailed information about clinical trials including interventions, trial arms, location, sponsor, trial conditions and more. Information is normalized, linked, and many relevant metadata descriptions are structured and ready for analysis.

Clinical Trial Arm Groups

Describes each group or subgroup of participants in the clinical trial that receives specific interventions related to the study protocol.

id
trial_id
kind
label
description
000008b4-f6e0-4ff4-9483-3369f59f6a63
NCT01232920
active_comparator
Mycophenolate mofetil
00000ebb-1ffc-43df-a496-2da813782f88
NCT06115408
experimental
Drug;N-Acetylcysteine
600 mg/day oral daily
000016ed-4a6f-4cd8-add3-5a5e5eef7a82
NCT01798745
experimental
Cohort D: JNJ-54452840 for 5 days
Each patient will receive JNJ-54452840 once daily for 5 days at a dose determined by the Data Monitoring Committee (daily dose not exceeding 240 mg).
000069a7-9ab3-427f-9735-00b0a4e2cfe8
NCT05321706
placebo_comparator
Placebo
Participants will be randomized in a 1:1 fashion to receive a matching tablet once daily for one year.
00007875-d528-4445-b6b0-7601068667a7
NCT05479812
experimental
WTX-124 monotherapy dose expansion in advanced or metastatic RCC
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Clinical Trial Browse Conditions

Each row in this table describes a potential condition that was studied in the specific trial. Each browse condition is potentially matched to a DrugBank conditio which is indicated by the presence of a condition_id value.

id
trial_id
title
condition_id
0
NCT00000726
Acquired Immunodeficiency Syndrome
48294
1
NCT00000726
Communicable Diseases
28178
2
NCT00000726
HIV Infections
35016
3
NCT00000726
Immunologic Deficiency Syndromes
28099
4
NCT00000726
Cytomegalovirus Retinitis
283
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Clinical Trial Browse Interventions

Each row in this table describes a potential drug intervention that was studied in this trial. Each browse intervention is potentially matched to a DrugBank drug, indicated by the presence of a drug_id value.

id
trial_id
title
drug_id
0
NCT00000726
Foscarnet
529
1
NCT00000726
Phosphonoacetic Acid
2823
2
NCT00000179
Haloperidol decanoate
502
3
NCT00000179
Trazodone
656
4
NCT00000179
Haloperidol
502
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Clinical Trial Conditions

Indicates the disease, disorder, syndrome, illness, or injury that is being studied in the clinical trial.

trial_id
condition_id
NCT06207370
21
NCT01306058
46
NCT00513604
48
NCT00924001
48
NCT00301509
61
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Clinical Trial Countries

Describes the country in which the clinical trial was conducted.

trial_id
country
NCT00000102
United States
NCT00000105
United States
NCT00000116
United States
NCT00000117
United States
NCT00000119
United States
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Clinical Trial Ids

Indicates the unique identifier associated with the specific clinical trial.

id
trial_id
identifier
kind
0
NCT00000726
NCT00000726
primary
1
NCT00000726
ACTG 015
org_study_id
2
NCT00000726
FDA 20D
external
3
NCT00000726
10991
external
4
NCT00001302
NCT00001302
primary
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Clinical Trial Intervention Arm Groups

Describes the relationship between clinical trial interventions and arm groups. Each intervention is related to at least one arm group, and each arm group has at least one intervention.

intervention_id
arm_group_id
34a3fa97-9477-44e9-a16b-e30536b50591
000008b4-f6e0-4ff4-9483-3369f59f6a63
d36bea2f-1715-4e95-a574-40c2094e8c92
00000ebb-1ffc-43df-a496-2da813782f88
3987507a-3a67-4775-a6cc-5dd682e00d0f
000016ed-4a6f-4cd8-add3-5a5e5eef7a82
ec298768-6952-45b0-a7bb-f2ab7d7fd879
000069a7-9ab3-427f-9735-00b0a4e2cfe8
120d41fc-b3bb-4647-a248-f0e272c8d3b7
00007875-d528-4445-b6b0-7601068667a7
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Clinical Trial Interventions

Each row in this table describes an intervention (experimental drug, vaccine, medical device, etc.) that is recorded in the referenced clinical trial.

id
trial_id
kind
title
description
0000418e-26ed-4068-8765-000622067c44
NCT04982380
drug
Siliankang simulating tablets
Patients will be instructed to continue current antidiabetic treatment, which should be kept unchanged throughout the trial, and start treatment with Siliankang simulative tablets 3 tablets p.o. tid for 12 weeks.
00004645-6318-4239-86ca-127207ead9cb
NCT01097486
procedure
Allograft
Single Dose Allograft Surgical Implantation
00006a6b-958b-438f-be34-fae8b88fafda
NCT06338826
drug
TDF - 245mg or TAF -25mg associated to 3TC - 300mg or FTC - 200mg and a NNRTI or PI/r or INSTI
The study will include patients under current daily antiretroviral tritherapy not modified for ≥ 12 months must including tenofovir disoproxil fumarate (TDF) 245mg or tenofovir alafenamide fumarate (TAF -25mg) associated to lamivudine (3TC - 300mg) or emtricitabine (FTC - 200mg) and a NNRTI or PI/r or INSTI to choose from NNRTI = efavirenz, rilpivirine, etravirine, doravirine PI/r = atazanavir/r ou darunavir/r INSTI = bictegravir, dolutegravir, elvitegravir/cobicistat, raltegravir
00007b19-8b85-422b-81cb-496b74cf195c
NCT04721054
drug
Thoracic epidural effect on heart rate in Laparoscopic Cholecystectomy (bupivacaine and lignocaine)
patients in epidural anesthesia were given epidural anesthesia and assessed for heart rate and mean arterial pressure
000097c5-d490-44ce-bc7e-eb473e8ccd78
NCT04417907
drug
Perampanel 4mg
Healthy adults will take 4mg perampanel PO QD for six weeks
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Clinical Trial Intervention Drugs

Describes the relationship between clinical trial interventions and DrugBank drugs. Each intervention is related to one or more drugs.

id
intervention_id
drug_id
0
8f38e770-d936-4484-9823-47910c3ec57f
529
1
cbdc0507-bfda-4f1d-b0cb-ec29a3b3eed8
11951
2
f3a5cb19-e734-4dc6-8a68-3906fb6725e7
656
3
887b7097-5b00-4138-9734-2a0c9ecd083e
502
4
7c8c40e6-872d-4dee-81e2-c48cad4e7a59
245
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Clinical Trial Intervention Names

Each row in this table describes an additional name, synonym, or code used by the clinical trial sponsors for a given intervention.

id
intervention_id
name
0
72bf20ce-9e35-452a-9fb0-5278e331ffc4
elavil plus prozac
1
a09d3d37-3a38-4798-bade-ac1c9d4383eb
Elavil
2
88525cb1-9c27-4be5-a4c4-0057fecbb8c8
Subutex
3
88525cb1-9c27-4be5-a4c4-0057fecbb8c8
Suboxone
4
f354cce2-1963-4e14-95d9-a3c8aa29ff15
Revia
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Clinical Trial Intervention Products

Describes the relationship between clinical trial interventions and DrugBank products, if the product is available.

id
intervention_id
product_id
0
8f38e770-d936-4484-9823-47910c3ec57f
413284
1
f3a5cb19-e734-4dc6-8a68-3906fb6725e7
94335
2
887b7097-5b00-4138-9734-2a0c9ecd083e
464755
3
1c9dd64d-84fd-41af-833e-01b664d9aa1c
469533
4
86894763-b424-4483-9135-d50dbc18b2fb
465274
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Clinical Trial Phases

Each row in this table describes the drug development phase (1, 2, 3, or 4) for a given clinical trial.

trial_id
phase
NCT00017381
0
NCT00091286
0
NCT00140556
0
NCT00176059
0
NCT00187941
0
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Clinical Trial Sponsors

Indicates the lead sponsor of the clinical trial.

id
trial_id
title
agency_class
lead_sponsor
0
NCT00000726
National Institute of Allergy and Infectious Diseases (NIAID)
nih
1
1
NCT00001302
National Cancer Institute (NCI)
nih
1
2
NCT00000179
National Institute on Aging (NIA)
nih
1
3
NCT00000333
National Institute on Drug Abuse (NIDA)
nih
1
4
NCT00000333
Washington D.C. Veterans Affairs Medical Center
us_fed
0
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Clinical Trials

Clinical trials are found in the clinical_trials table. Each row represents an individual clinical trial.

identifier
title
official_title
status
purpose
expanded_access
why_stopped
why_stopped_category_id
start_date
end_date
end_date_kind
NCT00000102
Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic Targets
completed
treatment
1
NCT00000105
Vaccination With Tetanus and KLH to Assess Immune Responses.
Vaccination With Tetanus Toxoid and Keyhole Limpet Hemocyanin (KLH) to Assess Antigen-Specific Immune Responses
terminated
1
Replaced by another study.
2002-07-01
2012-03-01
actual
NCT00000114
Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa
completed
treatment
1
1984-05-01
1987-06-01
actual
NCT00000115
Randomized Trial of Acetazolamide for Uveitis-Associated Cystoid Macular Edema
completed
treatment
1
1990-12-01
1994-06-01
actual
NCT00000116
Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A
Clinical Trial of Docosahexaenoic Acid (DHA) in Patients With Retinitis Pigmentosa Receiving Vitamin A Treatment
completed
treatment
1
1996-05-01
2002-09-01
actual
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Clinical Trial Why Stopped Categories

Describes the categories for reasons why a clinical trial was stopped.

id
category
definition
safety_efficacy_concern
1
Business Decision
The trial has been terminated due to strategic decisions, administrative reasons, sponsor, or company decision.
0
6
Change in Medical/Clinical Practices
The drug(s) of interest might not be suitable to the disease that they were trying to treat due to changes in medical or clinical practices. 1. Surgeons stopped doing procedures 2. Additional published information on the topic since starting the study 3. Study no longer consistent with current clinical practice
0
11
Competing Studies
The study drug(s) are having worse/futile results in similar competing trials.
0
16
Completed
Trial was successfully completed (user input was incorrectly marked as terminated). [eg. accrual was reached]
0
21
Conflict of Interest
The parties involved had conflicts of interests.
0
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Showing 15 of 15 tables

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