Voltage-dependent L-type calcium channel subunit beta-3
Details
- Name
- Voltage-dependent L-type calcium channel subunit beta-3
- Synonyms
- CAB3
- CACNLB3
- Calcium channel voltage-dependent subunit beta 3
- Gene Name
- CACNB3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004631|Voltage-dependent L-type calcium channel subunit beta-3 MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPV AFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPS PQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPV VLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIER SSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVL QRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRAT HHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQR SSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWP KDSY
- Number of residues
- 484
- Molecular Weight
- 54531.425
- Theoretical pI
- 6.31
- GO Classification
- Functionshigh voltage-gated calcium channel activity / voltage-gated calcium channel activityProcessesaxon guidance / calcium ion transport / membrane depolarization / neuromuscular junction development / regulation of voltage-gated calcium channel activity / synaptic transmission / T cell receptor signaling pathway / transportComponentsapical plasma membrane / cytosol / membrane / voltage-gated calcium channel complex
- General Function
- Voltage-gated calcium channel activity
- Specific Function
- The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019274|Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) ATGTATGACGACTCCTACGTGCCCGGGTTTGAGGACTCGGAGGCGGGTTCAGCCGACTCC TACACCAGCCGCCCATCTCTGGACTCAGACGTCTCCCTGGAGGAGGACCGGGAGAGTGCC CGGCGTGAAGTAGAGAGCCAGGCTCAGCAGCAGCTCGAAAGGGCCAAGCACAAACCTGTG GCATTTGCGGTGAGGACCAATGTCAGCTACTGTGGCGTACTGGATGAGGAGTGCCCAGTC CAGGGCTCTGGAGTCAACTTTGAGGCCAAAGATTTTCTGCACATTAAAGAGAAGTACAGC AATGACTGGTGGATCGGGCGGCTAGTGAAAGAGGGCGGGGACATCGCCTTCATCCCCAGC CCCCAGCGCCTGGAGAGCATCCGGCTCAAACAGGAGCAGAAGGCCAGGAGATCTGGGAAC CCTTCCAGCCTGAGTGACATTGGCAACCGACGCTCCCCTCCGCCATCTCTAGCCAAGCAG AAGCAAAAGCAGGCGGAACATGTTCCCCCATATGACGTGGTGCCCTCCATGCGGCCTGTG GTGCTGGTGGGACCCTCTCTGAAAGGTTATGAGGTCACAGACATGATGCAGAAGGCTCTC TTCGACTTCCTCAAACACAGATTTGATGGCAGGATCTCCATCACCCGAGTCACAGCCGAC CTCTCCCTGGCAAAGCGATCTGTGCTCAACAATCCGGGCAAGAGGACCATCATTGAGCGC TCCTCTGCCCGCTCCAGCATTGCGGAAGTGCAGAGTGAGATCGAGCGCATATTTGAGCTG GCCAAATCCCTGCAGCTAGTAGTGTTGGACGCTGACACCATCAACCACCCAGCACAGCTG GCCAAGACCTCGCTGGCCCCCATCATCGTCTTTGTCAAAGTGTCCTCACCAAAGGTACTC CAGCGTCTCATTCGCTCCCGGGGGAAGTCACAGATGAAGCACCTGACCGTACAGATGATG GCATATGATAAGCTGGTTCAGTGCCCACCGGAGTCATTTGATGTGATTCTGGATGAGAAC CAGCTGGAGGATGCCTGTGAGCACCTGGCTGAGTACCTGGAGGTTTACTGGCGGGCCACG CACCACCCAGCCCCTGGCCCCGGACTTCTGGGTCCTCCCAGTGCCATCCCCGGACTTCAG AACCAGCAGCTGCTGGGGGAGCGTGGCGAGGAGCACTCCCCCCTTGAGCGGGACAGCTTG ATGCCCTCTGATGAGGCCAGCGAGAGCTCCCGCCAAGCCTGGACAGGATCTTCACAGCGT AGCTCCCGCCACCTGGAGGAGGACTATGCAGATGCCTACCAGGACCTGTACCAGCCTCAC CGCCAACACACCTCGGGGCTGCCTAGTGCTAACGGGCATGACCCCCAAGACCGGCTTCTA GCCCAGGACTCAGAGCACAACCACAGTGACCGGAACTGGCAGCGCAACCGGCCTTGGCCC AAGGATAGCTACTGA
- Chromosome Location
- 12
- Locus
- 12q13
- External Identifiers
Resource Link UniProtKB ID P54284 UniProtKB Entry Name CACB3_HUMAN GenBank Protein ID 435135 GenBank Gene ID X76555 GenAtlas ID CACNB3 HGNC ID HGNC:1403 - General References
- Yamada Y, Masuda K, Li Q, Ihara Y, Kubota A, Miura T, Nakamura K, Fujii Y, Seino S, Seino Y: The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. Genomics. 1995 May 20;27(2):312-9. [Article]
- Collin T, Lory P, Taviaux S, Courtieu C, Guilbault P, Berta P, Nargeot J: Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit. Eur J Biochem. 1994 Feb 15;220(1):257-62. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04855 Dronedarone approved yes inhibitor Details DB00393 Nimodipine approved, investigational yes inhibitor Details DB01388 Mibefradil investigational, withdrawn yes inhibitor Details DB11148 Butamben approved, withdrawn yes inhibitor Details DB13746 Bioallethrin approved, experimental unknown agonist Details DB00153 Ergocalciferol approved, nutraceutical no inducer Details DB00228 Enflurane approved, investigational, vet_approved yes inhibitoractivator Details DB00661 Verapamil approved unknown inhibitor Details DB00622 Nicardipine approved, investigational unknown inhibitor Details DB09235 Efonidipine experimental yes inhibitor Details DB06751 Drotaverine approved, investigational unknown inhibitor Details DB11093 Calcium citrate approved, investigational unknown substrate Details DB11348 Calcium Phosphate approved unknown substrate Details DB09089 Trimebutine approved yes inhibitor Details DB09238 Manidipine approved, investigational yes blocker Details DB09236 Lacidipine approved, investigational yes antagonist Details DB09231 Benidipine experimental yes antagonist Details DB09232 Cilnidipine investigational yes antagonist Details DB13746 Bioallethrin approved, experimental unknown blocker Details DB00825 Levomenthol approved yes antagonist Details DB14481 Calcium phosphate dihydrate approved unknown Details DB00252 Phenytoin approved, vet_approved yes inhibitor Details DB00653 Magnesium sulfate approved, investigational, vet_approved yes inhibitorblocker Details DB01054 Nitrendipine approved, investigational unknown inhibitor Details DB00421 Spironolactone approved unknown inhibitor Details DB01118 Amiodarone approved, investigational unknown inhibitor Details DB13961 Fish oil approved, nutraceutical unknown inhibitor Details DB00243 Ranolazine approved, investigational unknown inhibitor Details DB00273 Topiramate approved yes antagonist Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details DB09235 Efonidipine experimental yes blocker Details DB06712 Nilvadipine approved, investigational unknown blocker Details