Tigecycline: a review of properties, applications, and analytical methods.
Article Details
- CitationCopy to clipboard
da Silva LM, Nunes Salgado HR
Tigecycline: a review of properties, applications, and analytical methods.
Ther Drug Monit. 2010 Jun;32(3):282-8. doi: 10.1097/FTD.0b013e3181dda54f.
- PubMed ID
- 20431506 [ View in PubMed]
- Abstract
Tigecycline is a new glycylcycline with an expanded broad-spectrum antibiotic, including inhibition of Gram-positive, Gram-negative, atypical, anaerobic, and antibiotic-resistant organisms. Trials have demonstrated that tigecycline is noninferior to the comparators for the treatment of complicated skin and skin structure infections as well as complicated intra-abdominal infections. Tigecycline is only available as an intravenous preparation and analytical methods to its quantitation in pharmaceutical products has not been published to date. This review examined tigecycline characteristics, the spectrum and mechanism of action, pharmacokinetics, applications, and, mainly, the instrumental conditions of published chromatographic methods used to measure tigecycline, its metabolites, and some analogs in clinical and biologic research.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tigecycline 16S ribosomal RNA Nucleotide Enteric bacteria and other eubacteria YesBinderDetails Tigecycline 30S ribosomal protein S12 Protein Escherichia coli (strain K12) YesBinderDetails Tigecycline 30S ribosomal protein S13 Protein Escherichia coli (strain K12) YesBinderDetails Tigecycline 30S ribosomal protein S14 Protein Escherichia coli (strain K12) YesBinderDetails Tigecycline 30S ribosomal protein S19 Protein Escherichia coli (strain K12) YesBinderDetails Tigecycline 30S ribosomal protein S9 Protein Escherichia coli (strain K12) YesBinderDetails