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Claude · drugbank-mcp
Which approved GLP-1R agonists have a half-life long enough for weekly dosing?
drugbank-mcp · structured pharmacology · 11 approved, 9 with a published half-life
Three. The class runs from 26 minutes to 168 hours, and the labels report it in minutes, hours and days, so I sorted on the normalized value.
Half-life · approved GLP-1R agonists
9 of 11
| Drug | As published | Normalized |
|---|---|---|
| Glucagon | 26 minutes | 0.43 h |
| Pramlintide | 48 minutes | 0.80 h |
| Exenatide | 2.4 hours | 2.4 h |
| Liraglutide | 13 hours | 13 h |
| Weekly dosing threshold · 24 h | ||
| Dulaglutide | 3.75 days | 89.9 h |
| Tirzepatide | 5 days | 120 h |
| Semaglutide | 168 hours | 168 h |
Avexitide is an antagonist at this receptor. Excluded. · Release 1423972