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Claude · drugbank-mcp
Which approved GLP-1R agonists have a half-life long enough for weekly dosing?
drugbank-mcp · structured pharmacology · 11 approved, 9 with a published half-life
Three. The class runs from 26 minutes to 168 hours, and the labels report it in minutes, hours and days, so I sorted on the normalized value.
Half-life · approved GLP-1R agonists 9 of 11
Drug As published Normalized
Glucagon 26 minutes 0.43 h
Pramlintide 48 minutes 0.80 h
Exenatide 2.4 hours 2.4 h
Liraglutide 13 hours 13 h
Weekly dosing threshold · 24 h
Dulaglutide 3.75 days 89.9 h
Tirzepatide 5 days 120 h
Semaglutide 168 hours 168 h
Avexitide is an antagonist at this receptor. Excluded. · Release 1423972

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