Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block.

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Wang C, Takeuchi K, Pinto LH, Lamb RA

Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block.

J Virol. 1993 Sep;67(9):5585-94.

PubMed ID

7688826 [ View in PubMed

]

Abstract

The influenza A virus M2 integral membrane protein has ion channel activity which can be blocked by the antiviral drug amantadine. The M2 protein transmembrane domain is highly conserved in amino acid sequence for all the human, swine, equine, and avian strains of influenza A virus, and thus, known amino acid differences could lead to altered properties of the M2 ion channel. We have expressed in oocytes of Xenopus laevis the M2 protein of human influenza virus A/Udorn/72 and the avian virus A/chicken/Germany/34 (fowl plague virus, Rostock) and derivatives of the Rostock ion channel altered in the presumed pore region. The pH of activation of the M2 ion channels and amantadine block of the M2 ion channels were investigated. The channels were found to be activated by pH in a similar manner but differed in their apparent Kis for amantadine block.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Amantadine	Matrix protein 2	Protein	Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)	Yes	Inhibitor	Details