Amylin receptors: molecular composition and pharmacology.
Article Details
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Hay DL, Christopoulos G, Christopoulos A, Sexton PM
Amylin receptors: molecular composition and pharmacology.
Biochem Soc Trans. 2004 Nov;32(Pt 5):865-7.
- PubMed ID
- 15494035 [ View in PubMed]
- Abstract
Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT((a))) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Pramlintide Calcitonin receptor Protein Humans YesAgonistDetails Pramlintide Receptor activity-modifying protein 1 Protein Humans YesAgonistDetails Pramlintide Receptor activity-modifying protein 2 Protein Humans YesAgonistDetails Pramlintide Receptor activity-modifying protein 3 Protein Humans YesAgonistDetails