TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol.

Article Details

Citation

Namer B, Seifert F, Handwerker HO, Maihofner C

TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol.

Neuroreport. 2005 Jun 21;16(9):955-9.

PubMed ID
15931068 [ View in PubMed
]
Abstract

The aim of this study was to evaluate the psychophysical effects of both TRPA1 and TRPM8 activation in humans by application of either cinnamaldehyde or menthol. We applied 10% cinnamaldehyde or 40% menthol solutions on the forearm in 10 study participants. Quantitative sensory testing and laser Doppler imaging was performed before and after exposure to the compounds. Cinnamaldehyde evoked significant spontaneous pain and induced heat and mechanical hyperalgesia, cold hypoalgesia and a neurogenic axon reflex erythema. In contrast, TRPM8 activation by menthol produced no axon reflex reaction and resulted in cold hyperalgesia. We conclude that agonists of TRPA1 and TRPM8 channels produce strikingly different psychophysical patterns.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
LevomentholTransient receptor potential cation channel subfamily A member 1ProteinHumans
Yes
Inducer
Details