Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia.

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Nicolas P, Li CH

Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia.

Proc Natl Acad Sci U S A. 1985 May;82(10):3178-81.

PubMed ID

2987913 [ View in PubMed

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Abstract

The potent opioid peptide beta-endorphin is found in the brain and pituitary with two related fragments, beta-endorphin-(1-27) and beta-endorphin-(1-26). The fragments retain substantial opioid-receptor binding activity but are virtually inactive analgesically. beta-Endorphin-(1-27) inhibits beta-endorphin-induced and etorphine-induced analgesia when coinjected intracerebroventricularly into mice. Antagonism by competition at the same site(s) is suggested from parallel shifts of the dose-response curves of etorphine or beta-endorphin in the presence of beta-endorphin-(1-27). Its potency is 4-5 times greater than that of the opiate antagonist naloxone. beta-Endorphin-(1-26) does not antagonize the antinociceptive action of etorphine or beta-endorphin in doses up to 500 pmol per animal.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Etorphine	Pro-opiomelanocortin	Protein	Humans	Unknown	Not Available	Details