Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines.

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Agwuh KN, MacGowan A

Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines.

J Antimicrob Chemother. 2006 Aug;58(2):256-65. Epub 2006 Jul 1.

PubMed ID

16816396 [ View in PubMed

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Abstract

The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline, is more reliably absorbed orally, while group 3, represented by the glycylcycline tigecycline, is injectable only, with an improved antibacterial spectrum compared with the tetracyclines. Though incompletely understood, the pharmacodynamic properties of the tetracyclines and glycylcyclines are summarized.

DrugBank Data that Cites this Article

Drugs

Doxycycline

Lymecycline

Oxytetracycline

Metacycline

Chlortetracycline

Meclocycline

Food Interactions

Drug	Interaction
Oxytetracycline	Avoid milk and dairy products. Take at least 1 hour before or two hours after consuming dairy products.
Oxytetracycline	Take separate from meals. Take at least one hour before or two hours after a meal.