The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors.
Article Details
- CitationCopy to clipboard
Golds PR, Przyslo FR, Strange PG
The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors.
Br J Pharmacol. 1980 Mar;68(3):541-9.
- PubMed ID
- 7052344 [ View in PubMed]
- Abstract
1 The binding of some antidepressant drugs, including some new drugs of atypical structure (flupenthixol, iprindole, maprotiline, mianserin, nomifensine, tofenacine and viloxazine) to muscarinic acetylcholine receptors in the brain has been studied by displacement of [3H]-atropine. 2 Many of the drugs are potent muscarinic antagonists. 3 Some correlation can be made between the affinity for binding to the muscarinic acetylcholine receptor and the incidence of anticholinergic side effects in clinical usage.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Flupentixol Muscarinic acetylcholine receptor M1 Protein Humans UnknownAntagonistDetails Maprotiline Muscarinic acetylcholine receptor M1 Protein Humans NoAntagonistDetails Maprotiline Muscarinic acetylcholine receptor M2 Protein Humans NoAntagonistDetails Maprotiline Muscarinic acetylcholine receptor M3 Protein Humans NoAntagonistDetails Maprotiline Muscarinic acetylcholine receptor M4 Protein Humans NoAntagonistDetails Maprotiline Muscarinic acetylcholine receptor M5 Protein Humans NoAntagonistDetails