A procedure for inducing sustained hyperlipemia in rats by administration of a surfactant.

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Levine S, Saltzman A

A procedure for inducing sustained hyperlipemia in rats by administration of a surfactant.

J Pharmacol Toxicol Methods. 2007 Mar-Apr;55(2):224-6. Epub 2006 Jun 3.

PubMed ID
16839786 [ View in PubMed
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Abstract

Tyloxapol (Triton WR 1339) is a non-ionic detergent that inhibits lipoprotein lipase and thereby raises levels of serum lipids. It is used frequently for acute studies on lipids in rats but not for subacute or chronic studies. In the present work, we found that tyloxapol must be injected intravenously three times each week in order to have high and sustained levels of serum cholesterol and triglycerides for 1, 2, or 3 weeks. These results make it possible to extend the use of tyloxapol into chronic studies of hyperlipemia and vascular disease.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
TyloxapolLipoprotein lipaseProteinHumans
Yes
Inhibitor
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