Management of ocular inflammation and pain following cataract surgery: focus on bromfenac ophthalmic solution.

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Cho H, Wolf KJ, Wolf EJ

Management of ocular inflammation and pain following cataract surgery: focus on bromfenac ophthalmic solution.

Clin Ophthalmol. 2009;3:199-210. Epub 2009 Jun 2.

PubMed ID

19668566 [ View in PubMed

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Abstract

Recently, several new ophthalmic NSAID products have been introduced for commercial use in the United States. The purpose of this review is to briefly overview the ophthalmic NSAIDs currently in use and to discuss the management of postoperative ocular inflammation and pain following cataract surgery with a particular focus on bromfenac ophthalmic solution 0.09%. Bromfenac ophthalmic solution 0.09% is indicated for the reduction of ocular pain and inflammation following cataract surgery. Studies have shown that bromfenac ophthalmic solution 0.09% has equivalent efficacy to the other topical NSAIDs in reducing postsurgical inflammation and controlling pain. The unique chemical structure of bromfenac makes it both a potent inhibitor of the COX-2 enzyme and a highly lipophilic molecule that rapidly penetrates to produce early and sustained drug levels in all ocular tissues. Clinically, these pharmacokinetic features are manifested in a rapid reduction of postsurgical inflammation and pain with bid dosing. Bromfenac ophthalmic solution 0.09% is a versatile agent and is effective when used as either monotherapy or as an adjunct therapy to steroids.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Bromfenac	Prostaglandin G/H synthase 2	Protein	Humans	Unknown	Inhibitor	Details