Proton pump inhibitors: new mechanisms of action.

Article Details

Citation

Tanus-Santos JE, Pinheiro LC

Proton pump inhibitors: new mechanisms of action.

Basic Clin Pharmacol Toxicol. 2019 Apr 13. doi: 10.1111/bcpt.13237.

PubMed ID
30980783 [ View in PubMed
]
Abstract

Proton pump inhibitors (PPIs) are drugs widely used to potently suppress gastric acid secretion in the therapy of gastroesophageal diseases. These drugs are activated in the acidic environment of the stomach and bind covalently to sulfhydryl groups of cysteines found in the proton pump (an H(+) ,K(+) -ATPase) inactivating it. This effect is irreversible and new H(+) ,K(+) -ATPase needs to be expressed in order to resume acid secretion. This article is protected by copyright. All rights reserved.

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