Mirtazapine: pharmacology in relation to adverse effects.

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Nutt D

Mirtazapine: pharmacology in relation to adverse effects.

Acta Psychiatr Scand Suppl. 1997;391:31-7.

PubMed ID

9265949 [ View in PubMed

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Abstract

Mirtazapine is a new antidepressant that falls into the general class of receptor-blocking drugs rather than being an uptake or enzyme inhibitor. It can be described as a noradrenergic and specific serotonergic antidepressant (NaSSA). The unique pharmacology of mirtazapine means that it has a very different side effect profile from the tricyclic antidepressants, producing less alpha 1 adrenergic and muscarinic blockade, and the selective serotonin reuptake inhibitors (SSRIs) and the serotonin-noradrenaline reuptake inhibitors (SNRIs), causing much less nausea and sexual dysfunction by virtue of its blockade of 5-HT2 and 5-HT3 receptors.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Mirtazapine	Alpha-1 adrenergic receptors (Protein Group)	Protein group	Humans	Unknown	Antagonist	Details