Methylprednisolone versus prednisolone pharmacokinetics in relation to dose in adults.
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Szefler SJ, Ebling WF, Georgitis JW, Jusko WJ
Methylprednisolone versus prednisolone pharmacokinetics in relation to dose in adults.
Eur J Clin Pharmacol. 1986;30(3):323-9. doi: 10.1007/bf00541537.
- PubMed ID
- 3732369 [ View in PubMed]
- Abstract
The disposition and plasma binding of methylprednisolone were examined in seven normal volunteers following the administration of 5, 20 and 40 mg of intravenous methylprednisolone sodium succinate. Methylprednisolone exhibits linear plasma protein binding averaging 77%. The mean plasma methylprednisolone clearance of 337 ml X h-1 X kg-1 was independent of dose. The steroid appears to moderately distribute into tissue spaces with a mean volume of distribution of 1.41 X kg-1. Methylprednisolone disposition parameters were compared with the non-transcortin bound parameters for prednisolone. The prednisolone plasma clearance based on the transcortin free-drug is similar to methylprednisolone total plasma clearance. However, the corrected volume of distribution of prednisolone is only one-half that of methylprednisolone. The disposition rate of these two steroids is thus similar, in spite of their metabolic control by different enzymatic pathways and major influence of saturable transcortin binding on prednisolone elimination.
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Methylprednisolone 11beta-hydroxysteroid dehydrogenase (Protein Group) Protein group Humans and other mammals UnknownNot Available Details Methylprednisolone 20-ketosteroid reductase (20-hydroxysteroid dehydrogenase) (Protein Group) Protein group Humans and other mammals UnknownSubstrateDetails