Topical promethazine side effects: our experience and review of the literature.

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Cantisani C, Ricci S, Grieco T, Paolino G, Faina V, Silvestri E, Calvieri S

Topical promethazine side effects: our experience and review of the literature.

Biomed Res Int. 2013;2013:151509. doi: 10.1155/2013/151509. Epub 2013 Nov 19.

PubMed ID

24350243 [ View in PubMed

]

Abstract

Promethazine hydrochloride is a first-generation H1 receptor antagonist, antihistamine, and antiemetic medication that can also have strong sedative effects. The apparent ability of topical H1r/2r antagonists to target epidermal H1/2r was translated into increased efficacy in the treatment of inflammatory dermatoses, likely due to decreased inflammation and enhanced barrier function.

DrugBank Data that Cites this Article

Drugs

Promethazine

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Promethazine	P2 Purinoceptors (Protein Group)	Protein group		Unknown	Inhibitor	Details
Promethazine	Voltage-gated Potassium Channels (Protein Group)	Protein group		Unknown	Inducer	Details
Promethazine	Voltage-gated sodium channel alpha subunit (Protein Group)	Protein group	Humans	Unknown	Inhibitor	Details