Topical promethazine side effects: our experience and review of the literature.

Article Details

Citation

Cantisani C, Ricci S, Grieco T, Paolino G, Faina V, Silvestri E, Calvieri S

Topical promethazine side effects: our experience and review of the literature.

Biomed Res Int. 2013;2013:151509. doi: 10.1155/2013/151509. Epub 2013 Nov 19.

PubMed ID
24350243 [ View in PubMed
]
Abstract

Promethazine hydrochloride is a first-generation H1 receptor antagonist, antihistamine, and antiemetic medication that can also have strong sedative effects. The apparent ability of topical H1r/2r antagonists to target epidermal H1/2r was translated into increased efficacy in the treatment of inflammatory dermatoses, likely due to decreased inflammation and enhanced barrier function.