Retinoic acid signaling pathways.
Article Details
- CitationCopy to clipboard
Ghyselinck NB, Duester G
Retinoic acid signaling pathways.
Development. 2019 Jul 4;146(13). pii: 146/13/dev167502. doi: 10.1242/dev.167502.
- PubMed ID
- 31273085 [ View in PubMed]
- Abstract
Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or repress transcription of key developmental genes. Genetic studies in mouse and zebrafish embryos that are deficient in RA-generating enzymes or RARs have been instrumental in identifying RA functions, revealing that RA signaling regulates development of many organs and tissues, including the body axis, spinal cord, forelimbs, heart, eye and reproductive tract. An understanding of the normal functions of RA signaling during development will guide efforts for use of RA as a therapeutic agent to improve human health. Here, we provide an overview of RA signaling and highlight its key functions during development.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Adapalene Retinoic acid receptor alpha Protein Humans UnknownNot Available Details Adapalene Retinoic acid receptor beta Protein Humans YesAgonistDetails Adapalene Retinoic acid receptor gamma Protein Humans YesAgonistDetails Adapalene Retinoic acid receptor RXR-alpha Protein Humans YesAgonistDetails Adapalene Retinoic acid receptor RXR-beta Protein Humans YesAgonistDetails Adapalene Retinoic acid receptor RXR-gamma Protein Humans YesAgonistDetails