Retinoic acid signaling pathways.

Article Details

Citation

Ghyselinck NB, Duester G

Retinoic acid signaling pathways.

Development. 2019 Jul 4;146(13). pii: 146/13/dev167502. doi: 10.1242/dev.167502.

PubMed ID
31273085 [ View in PubMed
]
Abstract

Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or repress transcription of key developmental genes. Genetic studies in mouse and zebrafish embryos that are deficient in RA-generating enzymes or RARs have been instrumental in identifying RA functions, revealing that RA signaling regulates development of many organs and tissues, including the body axis, spinal cord, forelimbs, heart, eye and reproductive tract. An understanding of the normal functions of RA signaling during development will guide efforts for use of RA as a therapeutic agent to improve human health. Here, we provide an overview of RA signaling and highlight its key functions during development.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
AdapaleneRetinoic acid receptor alphaProteinHumans
Unknown
Not AvailableDetails
AdapaleneRetinoic acid receptor betaProteinHumans
Yes
Agonist
Details
AdapaleneRetinoic acid receptor gammaProteinHumans
Yes
Agonist
Details
AdapaleneRetinoic acid receptor RXR-alphaProteinHumans
Yes
Agonist
Details
AdapaleneRetinoic acid receptor RXR-betaProteinHumans
Yes
Agonist
Details
AdapaleneRetinoic acid receptor RXR-gammaProteinHumans
Yes
Agonist
Details