Fatty acids and expression of adipokines.

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Drevon CA

Fatty acids and expression of adipokines.

Biochim Biophys Acta. 2005 May 30;1740(2):287-92. Epub 2004 Dec 8.

PubMed ID

15949695 [ View in PubMed

]

Abstract

Adipose tissue has been recognised as the quantitatively most important energy store of the human body for many years, in addition to its functions as mechanical and thermic insulator. In mammals, the adipose organ is localised in several depots including white as well as brown adipose tissues. The largest depots are found subcutaneously and in the abdominal region. Several secretory proteins are synthesised in adipose tissue including leptin, resistin, adiponectin, tumor necrosis factor (TNFalpha), angiotensinogen, adipsin, acylation-stimulating protein, retinol-binding protein (RBP), interleukin (IL)-1b, IL-6, IL-8, IL-10, plasminogen activator inhibitor-1 (PAI-1), fasting-induced adipose factor, fibrinogen-angiopoietin-related protein, metallothionein, tissue factor (TF), complement C3, fibronectin, haptoglobin, entactin/nidogen, collagen VI alpha 3, pigment epithelium-derived factor (PEDF), hippocampal cholinergic neurostimulating peptide (HCNP), neutrophil gelatinase-associated lipocalin (NGAL) and adiponutrin. Fatty acids may influence the expression of adipokines like leptin, resistin or adiponectin directly by interaction with transcription factors, or indirectly via unknown mechanisms possibly linked to fatty acid oxidation, synthesis or storage. Because fatty acids are the main components of adipose tissue, it is of essential interest to clarify the biological effects of different types of fatty acids on the expression of relevant adipokines.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Rosiglitazone	Peroxisome proliferator-activated receptor alpha	Protein	Humans	Unknown	Not Available	Details

Pharmaco-transcriptomics

Drug	Drug Groups	Gene	Gene ID	Change	Interaction	Chromosome
Arachidonic Acid	Experimental	RETN	56729	downregulated	Arachidonic Acid results in decreased expression of RETN mRNA	19p13.2
Icosapent	Approved Nutraceutical	LEP	3952	downregulated	Eicosapentaenoic Acid results in decreased expression of LEP mRNA	7q32.1
Icosapent	Approved Nutraceutical	RETN	56729	downregulated	Eicosapentaenoic Acid results in decreased expression of RETN mRNA	19p13.2
Icosapent	Approved Nutraceutical	SREBF1	6720	downregulated	Eicosapentaenoic Acid results in decreased expression of SREBF1 mRNA	17p11.2
Oleic Acid	Approved Investigational Vet Approved	SREBF1	6720	downregulated	Oleic Acid results in decreased expression of SREBF1 mRNA	17p11.2
Rosiglitazone	Approved Investigational	LEP	3952	downregulated	rosiglitazone results in decreased expression of LEP mRNA	7q32.1