Quetiapine treatment of children and adolescents with Tourette's disorder.

Article Details

Citation

Mukaddes NM, Abali O

Quetiapine treatment of children and adolescents with Tourette's disorder.

J Child Adolesc Psychopharmacol. 2003 Fall;13(3):295-9.

PubMed ID
14642017 [ View in PubMed
]
Abstract

OBJECTIVE: The purpose of this study was to investigate the short-term safety and effectiveness of quetiapine in the treatment of children and adolescents with Tourette's disorder. METHODS: This was an 8-week, open-label trial that included 12 subjects with a mean age of 11.4 +/- 2.4 years. The subjects were seen every week throughout the study. RESULTS: Clinical responses, as measured by the Turkish version of the Yale Global Tic Severity Scale, revealed a statistically significant reduction in tic scores ranging from 30-100%. Mean dose of quetiapine at the end of the study was 72.9 +/- 22.5 mg/day. Three subjects complained of sedation in the first week of treatment. CONCLUSIONS: The favorable results of this open-label study should be interpreted with caution due to the uncontrolled nature of the study. Spontaneous waxing and waning of symptoms should also be considered. Further controlled studies are required.

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