Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray.
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Miki Y, Suzuki T, Tazawa C, Ishizuka M, Semba S, Gorai I, Sasano H
Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray.
Cancer Lett. 2005 Apr 8;220(2):197-210.
- PubMed ID
- 15766595 [ View in PubMed]
- Abstract
The Mullerian ducts are strongly influenced by natural estrogen, estradiol (E2) and diethylstilbestrol (DES) in their development. We screened E2 and DES responsive genes using a microarray analysis in human primitive Mullerian duct cell line, EMTOKA cells expressed estrogen receptor (ER) beta. c-myc oncogene and other target genes expression was detected in cells treated by high-dose DES, but ER antagonist ICI 182,780 could not prevent c-myc induction above. Results of our present study suggested the presence of ER independent pathway in oncogenes induction process by high-dose DES treatment in a human primitive Mullerian duct cell line.