The sensitization of glioma cells to cisplatin and tamoxifen by the use of catechin.
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Shervington A, Pawar V, Menon S, Thakkar D, Patel R
The sensitization of glioma cells to cisplatin and tamoxifen by the use of catechin.
Mol Biol Rep. 2009 May;36(5):1181-6. doi: 10.1007/s11033-008-9295-3. Epub 2008 Jun 26.
- PubMed ID
- 18581255 [ View in PubMed]
- Abstract
Telomerase expression strongly correlates with the grade of malignancy in glioma with inhibition illustrating a definite increase in chemosensitivity. This study was designed to investigate the effects of a green tea derivative, epigallocatechin-3-gallate (EGCG); together with either cisplatin or tamoxifen in glioma, and to investigate whether these effects are mediated through telomerase suppression. EGCG showed a significant cytotoxic effect on 1321N1 cells after 24 h and on U87-MG cells after 72 h (P < 0.001) without significantly affecting the normal astrocytes. Treatment with EGCG inhibited telomerase expression significantly (P < 0.01) and enhanced the effect of cisplatin and tamoxifen in both 1321N1 (P < 0.01) and U87-MG (P < 0.001) cells. EGCG, as a natural product has enormous potential to be an anti-cancer agent capable of enhancing tumour cell sensitivity to therapy.