[Estriol replacement therapy in osteoporotic women].

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Matsuo H

[Estriol replacement therapy in osteoporotic women].

Clin Calcium. 2002 Aug;12(8):1165-9.

PubMed ID

15775415 [ View in PubMed

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Abstract

In cultured human osteoblast-like cells (HOS), combined treatment with estriol (E(3)) and vitamin D(3) (VD(3)) increases the cell viability relative to treatment with E(3) alone and that E(3) treatment remarkably increases VD(3) receptor mRNA expression in the cells. Our findings in the present study with osteoblast cells may explain at least in a part the molecular basis of the clinical efficacy of combined treatment with E(3) and VD(3) in osteoporotic women.