Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa.

Article Details

Citation

Copy to clipboard

Davies TA, Shang W, Bush K, Flamm RK

Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa.

Antimicrob Agents Chemother. 2008 Apr;52(4):1510-2. doi: 10.1128/AAC.01529-07. Epub 2008 Feb 4.

PubMed ID

18250190 [ View in PubMed

]

Abstract

Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with doripenem.

DrugBank Data that Cites this Article

Drugs

Ceftazidime

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ceftazidime	Penicillin-binding protein 1A	Protein	Escherichia coli (strain K12)	Yes	Inhibitor	Details
Ceftazidime	Penicillin-binding protein 1B	Protein	Escherichia coli (strain K12)	Yes	Inhibitor	Details
Ceftazidime	Penicillin-binding protein 2	Protein	Escherichia coli (strain K12)	Yes	Inhibitor	Details
Ceftazidime	Peptidoglycan synthase FtsI	Protein	Escherichia coli (strain K12)	Yes	Inhibitor	Details