The synthesis and selective IL-2 inhibitory activity of bis piperazine-phenol Mannich adducts.
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Geng B, Fleming PR, Umlauf S, Lin A, Pallai PV
The synthesis and selective IL-2 inhibitory activity of bis piperazine-phenol Mannich adducts.
Bioorg Med Chem Lett. 2002 Mar 11;12(5):775-8.
- PubMed ID
- 11859000 [ View in PubMed]
- Abstract
Novel phenol bis-Mannich adducts were identified as IL-2 expression inhibitors in a T cell proliferation screening assay. Analogues of the lead compound were prepared through parallel synthesis and a highly selective IL-2 inhibitor was discovered that provided a suitable compound for further optimization.