[Mifepristone inhibits the progesterone-induced expressions of HLA-G, -E, -F genes in trophoblasts during first trimester].

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Zeng B, Wang Y, Zhang Y, Liao AH

[Mifepristone inhibits the progesterone-induced expressions of HLA-G, -E, -F genes in trophoblasts during first trimester].

Zhonghua Yi Xue Za Zhi. 2012 Jan 3;92(1):15-7.

PubMed ID

22490650 [ View in PubMed

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Abstract

OBJECTIVE: To explore the effects of mifepristone on the expressions of HLA-G, HLA-E and HLA-F in extravillous cytotrophoblasts (EVCT). METHODS: Cultured EVCT during the first trimester were treated in vitro with progesterone and mifepristone. And the transcription levels of HLA-G, HLA-E and HLA-F genes were detected by RT-PCR (reverse transcription-polymerase chain reaction). RESULTS: As compared with the controls, the levels of HLA-G, HLA-E and HLA-F mRNA significantly increased in EVCT after incubating with 0.1 ng/L progesterone (P < 0.05). These effects could be completely blocked by a co-incubation with mifepristone at the same concentrations. CONCLUSION: Mifepristone can inhibit the effects of progesterone by down-regulating the expressions of HLA-G, HLA-E and HLA-F mRNA in trophoblasts during the first trimester.