The effect of resveratrol on a cell model of human aging.
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Stefani M, Markus MA, Lin RC, Pinese M, Dawes IW, Morris BJ
The effect of resveratrol on a cell model of human aging.
Ann N Y Acad Sci. 2007 Oct;1114:407-18. Epub 2007 Sep 5.
- PubMed ID
- 17804521 [ View in PubMed]
- Abstract
The natural polyphenol resveratrol stimulates sirtuins and extends lifespan. Here resveratrol inhibited expression of replicative senescence marker INK4a in human dermal fibroblasts, and 47 of 19,000 genes from microarray experiments were differentially expressed. These included genes for growth, cell division, cell signaling, apoptosis, and transcription. Genes involved in Ras and ubiquitin pathways, Ras-GRF1, RAC3, and UBE2D3, were downregulated. The changes suggest resveratrol might alter sirtuin-regulated downstream pathways, rather than sirtuin activity. Serum deprivation and high confluency caused nuclear translocation of the SIRT1-regulated transcription factor FOXO3a. Our data indicate resveratrol's actions might cause FOXO recruitment to the nucleus.