High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage.
Article Details
- CitationCopy to clipboard
Xue W, Wang Z, Chen Q, Chen J, Yang H, Xue S
High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage.
Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8. doi: 10.1016/j.cca.2010.05.018. Epub 2010 May 15.
- PubMed ID
- 20478284 [ View in PubMed]
- Abstract
BACKGROUND: Although interactions of arsenite and selenite in mammalian organisms have been suggested by literature data, the antioxidant effects and biochemical mechanisms of dietary selenium on human populations exposed to inorganic arsenic are not fully understood. METHODS: Total blood, urine and hair concentrations of arsenic and selenium were determined in all individuals by hydride generation atomic fluorescence spectrometry. The individuals with skin lesions were subsequently classified as "High As group" and "High Se/As group" and controls were classified as "High Se group" and "Control group" according to their blood selenium concentrations. RESULTS: High selenium status was correlated with elevated activities of serum superoxide dismutase, glutathione peroxidase, catalase, and reduced levels of malondialdehyde, and increased RNA and protein expression of heme oxygenase-1 in peripheral blood mononuclear cells (PBMC) of individuals in the high arsenic group. Urinary 8-hydroxy-2'-deoxyguanosine levels were positively associated with blood arsenic, but inversely with blood and hair selenium among individuals with skin lesions, whereas mRNA are protein levels of 8-oxoganine DNA glycosylase 1 in PBMC increased in the "High Se/As group" compared to the "High As group". CONCLUSIONS: Inorganic arsenic exposure is associated with oxidative stress, which may be prevented by high selenium status via its antioxidative activity and detoxification effect possibly through the formation of an arsenic and selenium containing metabolite, the seleno-bis(S-glutathionyl) arsinium ion.
DrugBank Data that Cites this Article
- Pharmaco-transcriptomics
Drug Drug Groups Gene Gene ID Change Interaction Chromosome Selenium Approved Investigational Vet Approved HMOX1 3162 upregulated Selenium results in increased expression of HMOX1 mRNA 22q12.3 - Pharmaco-proteomics
Drug Drug Groups Gene Gene ID Change Interaction Chromosome Selenium Approved Investigational Vet Approved CAT 847 increased Selenium results in increased expression of CAT protein 11p13 Selenium Approved Investigational Vet Approved HMOX1 3162 increased Selenium results in increased expression of HMOX1 protein 22q12.3 Selenium Approved Investigational Vet Approved OGG1 4968 increased Selenium results in increased expression of OGG1 protein 3p25.3