[Effect of simvastatin on monocyte CX3CR1 expression in patients with acute coronary syndrome].
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Peng DD, Li ZL
[Effect of simvastatin on monocyte CX3CR1 expression in patients with acute coronary syndrome].
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):475-7.
- PubMed ID
- 18359719 [ View in PubMed]
- Abstract
OBJECTIVE: To observe the effect of simvastatin on expression of CX3CR1 in the monocytes in patients with acute coronary syndrome and investigate the non-lipid mechanisms of statins against atherosclerosis. METHODS: The expression of CX3CR1 in the monocytes was measured by quantitative real-time RT-PCR in 63 patients with acute coronary syndrome confirmed by coronary arteriography after treatment with simvastatin at 10(-7) approximately 10(-5) mol/L for 4, 8 and 12 h, respectively. RESULTS: CX3CR1 expression in the monocytes treated with different concentrations of simvastatin was significantly lower than that in the control cells (P<0.05), and the expression in the cells treated with the agent for different time lengths was also significantly lower than that in the control cells (P<0.01). CONCLUSION: Simvastatin can reduce CX3CR1 expression in the monocytes of the patients with acute coronary syndrome in a concentration- and time-dependent manner, so as to reduce the inflammation and stabilize the vascular plaques.