Changes in expression of WT1 isoforms during induced differentiation of the NB4 cell line.
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Gu W, Chen Z, Hu S, Shen H, Qiu G, Cao X
Changes in expression of WT1 isoforms during induced differentiation of the NB4 cell line.
Haematologica. 2005 Mar;90(3):403-5.
- PubMed ID
- 15749674 [ View in PubMed]
- Abstract
The levels of expression of WT1 gene and WT1+17AA isoforms rapidly decreased during the differentiation of NB4 cells induced by all-trans retinoic acid; this decrease was conversely related to the dynamic changes of CD11b positive cells, indicating that the abnormally high expression of WT1 gene and WT1+17AA isoforms was associated with a block of NB4 cell differentiation.