Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells.
Article Details
- CitationCopy to clipboard
Guo LW, Wu Q, Green B, Nolen G, Shi L, Losurdo J, Deng H, Bauer S, Fang JL, Ning B
Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells.
Toxicol Appl Pharmacol. 2012 Jul 15;262(2):117-23. doi: 10.1016/j.taap.2012.04.024. Epub 2012 May 1.
- PubMed ID
- 22726953 [ View in PubMed]
- Abstract
Humans at all ages are continually exposed to triclosan (TCS), a widely used antimicrobial agent that can be found in many daily hygiene products, such as toothpastes and shampoos; however, the toxicological and biological effects of TCS in the human body after long-term and low-concentration exposure are far from being well understood. In the current study, we investigated the effects of TCS on the differentiation of human mesenchymal stem cells (hMSCs) by measuring the cytotoxicity, morphological changes, lipid accumulation, and the expression of adipocyte differentiation biomarkers during 21-day adipogenesis. Significant cytotoxicity was observed in un-induced hMSCs treated with high-concentration TCS (>/= 5.0 muM TCS), but not with low-concentration treatments (