Evaluation of spectinomycin and gentamicin in the treatment of hospitalized patients with resistant urinary tract infections.

Article Details

Citation

Pickering LK, DuPont HL, Satterwhite TK

Evaluation of spectinomycin and gentamicin in the treatment of hospitalized patients with resistant urinary tract infections.

Am J Med Sci. 1977 Nov-Dec;274(3):291-6.

PubMed ID
147625 [ View in PubMed
]
Abstract

Spectinomycin hydrochloride 140 mg/kg/day and gentamicin 3 mg/kg/day were evaluated in the treatment of 50 hospitalized patients with urinary tract infections. Seven patients (28%) in the spectinomycin group had positive urine cultures after 72 hours of therapy due to initial resistance of the organism (5 isolates) or development of resistance to spectinomycin (2 isolates). Response to gentamicin therapy was uniformly satisfactory. Complications of spectinomycin therapy included pain and induration at the injection site (11 patients) and elevated serum creatinine values (2 patients). Ototoxicity was noted in three patients given gentamicin. Peak serum concentrations of spectinomycin (range 55-157 microgram/ml) and gentamicin (range 2.8--8.5 microgram/ml) showed marked interpatient variation. Spectinomycin appears to be of limited value in the treatment of urinary tract infections caused by gram-negative bacilli.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
SpectinomycinApproved Investigational Vet ApprovedCreatinine
increased
Spectinomycin increases the level of Creatinine in the blood