Muscarinic receptor antagonists: effects on pulmonary function.
Article Details
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Buels KS, Fryer AD
Muscarinic receptor antagonists: effects on pulmonary function.
Handb Exp Pharmacol. 2012;(208):317-41. doi: 10.1007/978-3-642-23274-9_14.
- PubMed ID
- 22222705 [ View in PubMed]
- Abstract
In healthy lungs, muscarinic receptors control smooth muscle tone, mucus secretion, vasodilation, and inflammation. In chronic obstructive pulmonary disease (COPD) and asthma, cholinergic mechanisms contribute to increased bronchoconstriction and mucus secretion that limit airflow. This chapter reviews neuronal and nonneuronal sources of acetylcholine in the lung and the expression and role of M(1), M(2), and M(3) muscarinic receptor subtypes in lung physiology. It also discusses the evidence for and against the role of parasympathetic nerves in asthma, and the current use and therapeutic potential of muscarinic receptor antagonists in COPD and asthma.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Atropine Muscarinic acetylcholine receptor M1 Protein Humans YesAntagonistDetails Atropine Muscarinic acetylcholine receptor M2 Protein Humans YesAntagonistDetails Atropine Muscarinic acetylcholine receptor M3 Protein Humans YesAntagonistDetails Atropine Muscarinic acetylcholine receptor M4 Protein Humans YesAntagonistDetails Atropine Muscarinic acetylcholine receptor M5 Protein Humans YesAntagonistDetails