The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.

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Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ

The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.

Antimicrob Agents Chemother. 1995 Jul;39(7):1629-31.

PubMed ID

7492120 [ View in PubMed

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Abstract

The Aeromonas hydrophila AE036 chromosome contains a cphA gene encoding a metallo-beta-lactamase which is highly active against carbapenem antibiotics such as imipenem. Here we show that the cphA gene product shares inhibitory similarities with a mammalian zinc peptidase, membrane dipeptidase (MDP; dehydropeptidase I). Both enzymes are able to hydrolyze imipenem and are inhibited by cilastatin. The active site similarities of these enzymes are not reflected in any significant primary sequence similarity.

DrugBank Data that Cites this Article

Drugs

Cilastatin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cilastatin	Dipeptidase 1	Protein	Humans	Yes	Inhibitor	Details