Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency.
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Beyer KH Jr, Ward TD, Vary JE, Gelarden RT, Knutson DW, Vesell ES
Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency.
J Clin Pharmacol. 1993 Jun;33(6):554-61.
- PubMed ID
- 8366180 [ View in PubMed]
- Abstract
A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency. Pyrazinoylguanidine was saluretic, without affecting serum potassium or glucose concentrations. The onset of PZG's antihypertensive effect occurred within 4 hours. In contrast, hydrochlorothiazide (HCTZ) increased serum concentrations of urea, triglycerides, and glucose, without affecting cholesterol.