Relationship between cisplatin or nedaplatin-induced nephrotoxicity and renal accumulation.

Article Details

Citation

Kawai Y, Taniuchi S, Okahara S, Nakamura M, Gemba M

Relationship between cisplatin or nedaplatin-induced nephrotoxicity and renal accumulation.

Biol Pharm Bull. 2005 Aug;28(8):1385-8.

PubMed ID
16079479 [ View in PubMed
]
Abstract

Nedaplatin is known to exhibit antitumor activity similar to that of cisplatin. However, concerning side effects, nedaplatin causes renal toxicity less frequently than cisplatin. In this study, we compared the incidence of renal toxicity between cisplatin and nedaplatin by investigating the difference in kidney tissue accumulation. Kidney tissue accumulation of cisplatin administered at 3.75 mg/kg was similar to that of nedaplatin administered at 24 mg/kg. At these doses, the plasma creatinine level and urinary excretion of glucose and N-acetyl-beta-D-glucosaminidase (NAG) similarly increased. There was a correlation between kidney accumulation of cisplatin and nedaplatin and the increases in plasma creatinine level and urinary excretion of NAG. Therefore, our results suggest that nedaplatin less frequently causes renal toxicity in comparison to cisplatin due to lower kidney accumulation.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
CisplatinApprovedCreatinine
increased
Cisplatin increases the level of Creatinine in the blood
NedaplatinApproved InvestigationalCreatinine
increased
Nedaplatin increases the level of Creatinine in the blood