Imidazo[1,2-b]pyridazine as privileged scaffold in medicinal chemistry: An extensive review.
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Garrido A, Vera G, Delaye PO, Enguehard-Gueiffier C
Imidazo[1,2-b]pyridazine as privileged scaffold in medicinal chemistry: An extensive review.
Eur J Med Chem. 2021 Dec 15;226:113867. doi: 10.1016/j.ejmech.2021.113867. Epub 2021 Sep 23.
- PubMed ID
- 34607244 [ View in PubMed]
- Abstract
Imidazo[1,2-b]pyridazine scaffold represents an important class of heterocyclic nucleus which provides various bioactives molecules. Among them, the successful kinase inhibitor ponatinib led to a resurgence of interest in exploring new imidazo[1,2-b]pyridazine-containing derivatives for their putative therapeutic applications in medicine. This present review intends to provide a state-of-the-art of this framework in medicinal chemistry from 1966 to nowadays, unveiling different aspects of its structure-activity relationships (SAR). This extensive literature surveil may guide medicinal chemists for the quest of novel imidazo[1,2-b]pyridazine compounds with enhanced pharmacokinetics profile and efficiency.