3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

Article Details

Citation

Copy to clipboard

Kulagowski JJ, Broughton HB, Curtis NR, Mawer IM, Ridgill MP, Baker R, Emms F, Freedman SB, Marwood R, Patel S, Patel S, Ragan CI, Leeson PD

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

J Med Chem. 1996 May 10;39(10):1941-2.

PubMed ID

8642550 [ View in PubMed

]

Abstract

Not Available

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Clozapine	Dopamine D2 receptor	Ki (nM)	74	N/A	N/A	Details
Clozapine	Dopamine D3 receptor	Ki (nM)	200	N/A	N/A	Details
Clozapine	Dopamine D4 receptor	Ki (nM)	10	N/A	N/A	Details
Haloperidol	Dopamine D2 receptor	Ki (nM)	1.4	N/A	N/A	Details
Haloperidol	Dopamine D3 receptor	Ki (nM)	2	N/A	N/A	Details