5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

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Rowley M, Broughton HB, Collins I, Baker R, Emms F, Marwood R, Patel S, Patel S, Ragan CI, Freedman SB, Leeson PD

5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

J Med Chem. 1996 May 10;39(10):1943-5.

PubMed ID

8642551 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Clozapine	Dopamine D2 receptor	Ki (nM)	74	N/A	N/A	Details
Clozapine	Dopamine D3 receptor	Ki (nM)	200	N/A	N/A	Details
Clozapine	Dopamine D4 receptor	Ki (nM)	10	N/A	N/A	Details
Haloperidol	Dopamine D2 receptor	Ki (nM)	1.4	N/A	N/A	Details
Haloperidol	Dopamine D3 receptor	Ki (nM)	2	N/A	N/A	Details