2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors.

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Thurkauf A, Yuan J, Chen X, He XS, Wasley JW, Hutchison A, Woodruff KH, Meade R, Hoffman DC, Donovan H, Jones-Hertzog DK

2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors.

J Med Chem. 1997 Jan 3;40(1):1-3.

PubMed ID

9016321 [ View in PubMed

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Clozapine	Dopamine D2 receptor	Ki (nM)	254	N/A	N/A	Details
Clozapine	Dopamine D3 receptor	Ki (nM)	454	N/A	N/A	Details
Clozapine	Dopamine D4 receptor	Ki (nM)	70	N/A	N/A	Details
Haloperidol	Dopamine D2 receptor	Ki (nM)	4.8	N/A	N/A	Details