N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.

Article Details

Citation

Copy to clipboard

Fish PV, Fray MJ, Stobie A, Wakenhut F, Whitlock GA

N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):2022-5. Epub 2007 Jan 19.

PubMed ID

17267217 [ View in PubMed

]

Abstract

A series of N-benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amine monoamine reuptake inhibitors are described. Selective dual 5-HT and NA reuptake inhibition was achieved, and analogues with weak CYP2D6 inhibition, good human in vitro metabolic stability and wide ligand selectivity, such as 12b, were identified.