Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.

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Ennis MD, Ghazal NB, Hoffman RL, Smith MW, Schlachter SK, Lawson CF, Im WB, Pregenzer JF, Svensson KA, Lewis RA, Hall ED, Sutter DM, Harris LT, McCall RB

Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.

J Med Chem. 1998 Jun 18;41(13):2180-3.

PubMed ID

9632349 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Sumatriptan	5-hydroxytryptamine receptor 1A	Ki (nM)	341	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1B	Ki (nM)	6.4	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1D	Ki (nM)	2	N/A	N/A	Details