Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.
Article Details
- CitationCopy to clipboard
Johnson AT, Klein ES, Gillett SJ, Wang L, Song TK, Pino ME, Chandraratna RA
Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.
J Med Chem. 1995 Nov 24;38(24):4764-7.
- PubMed ID
- 7490725 [ View in PubMed]
- Abstract
Not Available
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Tretinoin Retinoic acid receptor alpha EC 50 (nM) 7 N/A N/A Details Tretinoin Retinoic acid receptor beta Kd (nM) 12 N/A N/A Details Tretinoin Retinoic acid receptor beta EC 50 (nM) 1 N/A N/A Details Tretinoin Retinoic acid receptor gamma EC 50 (nM) 0.7 N/A N/A Details Tretinoin Retinoic acid receptor gamma Kd (nM) 19 N/A N/A Details Tretinoin Retinoic acid receptor RXR-alpha Kd (nM) 9 N/A N/A Details