Antidepressant principles of the roots of Polygala tenuifolia.

Article Details

Citation

Copy to clipboard

Cheng MC, Li CY, Ko HC, Ko FN, Lin YL, Wu TS

Antidepressant principles of the roots of Polygala tenuifolia.

J Nat Prod. 2006 Sep;69(9):1305-9.

PubMed ID

16989524 [ View in PubMed

]

Abstract

[(125)I]RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B (1 and 2) showed significant inhibitory activity, with IC(50) values of 30.0 and 6.04 microM, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Desipramine	Sodium-dependent noradrenaline transporter	IC 50 (nM)	0.93	N/A	N/A	Details