Antidepressant principles of the roots of Polygala tenuifolia.

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Cheng MC, Li CY, Ko HC, Ko FN, Lin YL, Wu TS

Antidepressant principles of the roots of Polygala tenuifolia.

J Nat Prod. 2006 Sep;69(9):1305-9.

PubMed ID

16989524 [ View in PubMed

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Abstract

[(125)I]RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B (1 and 2) showed significant inhibitory activity, with IC(50) values of 30.0 and 6.04 microM, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.