Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors.

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Xie HZ, Li LL, Ren JX, Zou J, Yang L, Wei YQ, Yang SY

Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1944-9. doi: 10.1016/j.bmcl.2009.02.049. Epub 2009 Feb 20.

PubMed ID

19254842 [ View in PubMed

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Abstract

In this investigation, chemical features based 3D pharmacophore models were developed based on the known inhibitors of Spleen tyrosine kinase (Syk) with the aid of hiphop and hyporefine modules within catalyst. The best quantitative pharmacophore model, Hypo1, was used as a 3D structural query for retrieving potential inhibitors from chemical databases including Specs, NCI, MayBridge, and Chinese Nature Product Database (CNPD). The hit compounds were subsequently subjected to filtering by Lipinski's rule of five and docking studies to refine the retrieved hits. Finally 30 compounds were selected from the top ranked hit compounds and conducted an in vitro kinase inhibitory assay. Six compounds showed a good inhibitory potency against Syk, which have been selected for further investigation.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Staurosporine	Tyrosine-protein kinase SYK	IC 50 (nM)	3	N/A	N/A	Details
Tamatinib	Tyrosine-protein kinase SYK	IC 50 (nM)	41	N/A	N/A	Details