Design and synthesis of novel isoxazole-based HDAC inhibitors.
Article Details
- CitationCopy to clipboard
Conti P, Tamborini L, Pinto A, Sola L, Ettari R, Mercurio C, De Micheli C
Design and synthesis of novel isoxazole-based HDAC inhibitors.
Eur J Med Chem. 2010 Sep;45(9):4331-8. doi: 10.1016/j.ejmech.2010.06.035. Epub 2010 Jun 30.
- PubMed ID
- 20637529 [ View in PubMed]
- Abstract
A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn(2+)-binding group in order to check its participation in the coordinating process.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Vorinostat Histone deacetylase 1 IC 50 (nM) 170 N/A N/A Details Vorinostat Histone deacetylase 2 IC 50 (nM) 390 N/A N/A Details Vorinostat Histone deacetylase 3 IC 50 (nM) 200 N/A N/A Details Vorinostat Histone deacetylase 6 IC 50 (nM) 9.3 N/A N/A Details