Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
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Jaroch S, Holscher P, Rehwinkel H, Sulzle D, Burton G, Hillmann M, McDonald FM
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
Bioorg Med Chem Lett. 2003 Jun 16;13(12):1981-4.
- PubMed ID
- 12781178 [ View in PubMed]
- Abstract
Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.