Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.

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Jaroch S, Holscher P, Rehwinkel H, Sulzle D, Burton G, Hillmann M, McDonald FM

Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):1981-4.

PubMed ID

12781178 [ View in PubMed

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Abstract

Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide	Nitric oxide synthase, brain	IC 50 (nM)	35	N/A	N/A	Details
N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide	Nitric oxide synthase, inducible	IC 50 (nM)	5000	N/A	N/A	Details