Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
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Grunewald GL, McLeish MJ, Criscione KR
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Bioorg Med Chem Lett. 2001 Jun 18;11(12):1579-82.
- PubMed ID
- 11412985 [ View in PubMed]
- Abstract
Epinephrine (Epi) acts as a neurotransmitter in the brain, but its function therein is not well understood. Phenylethanolamine N-methyltransferase (PNMT) catalyzes the final step in the biosynthesis of Epi and is thus a pharmacological target to investigate the function of Epi in the central nervous system. The kinetic differences between bovine adrenal PNMT and human brain PNMT for a number of substrates and inhibitors are examined and the results reported.