Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Article Details
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Grunewald GL, McLeish MJ, Criscione KR
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Bioorg Med Chem Lett. 2001 Jun 18;11(12):1579-82.
- PubMed ID
- 11412985 [ View in PubMed]
- Abstract
Epinephrine (Epi) acts as a neurotransmitter in the brain, but its function therein is not well understood. Phenylethanolamine N-methyltransferase (PNMT) catalyzes the final step in the biosynthesis of Epi and is thus a pharmacological target to investigate the function of Epi in the central nervous system. The kinetic differences between bovine adrenal PNMT and human brain PNMT for a number of substrates and inhibitors are examined and the results reported.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide Phenylethanolamine N-methyltransferase Ki (nM) 580 N/A N/A Details 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Phenylethanolamine N-methyltransferase Ki (nM) 300 N/A N/A Details 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine Phenylethanolamine N-methyltransferase Ki (nM) 280 N/A N/A Details