Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.

Article Details

Citation

Grunewald GL, McLeish MJ, Criscione KR

Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.

Bioorg Med Chem Lett. 2001 Jun 18;11(12):1579-82.

PubMed ID
11412985 [ View in PubMed
]
Abstract

Epinephrine (Epi) acts as a neurotransmitter in the brain, but its function therein is not well understood. Phenylethanolamine N-methyltransferase (PNMT) catalyzes the final step in the biosynthesis of Epi and is thus a pharmacological target to investigate the function of Epi in the central nervous system. The kinetic differences between bovine adrenal PNMT and human brain PNMT for a number of substrates and inhibitors are examined and the results reported.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid AmidePhenylethanolamine N-methyltransferaseKi (nM)580N/AN/ADetails
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolinePhenylethanolamine N-methyltransferaseKi (nM)300N/AN/ADetails
8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]AzepinePhenylethanolamine N-methyltransferaseKi (nM)280N/AN/ADetails