Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc.

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Lemoine RC, Petersen AC, Setti L, Baldinger T, Wanner J, Jekle A, Heilek G, deRosier A, Ji C, Rotstein DM

Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1674-6. doi: 10.1016/j.bmcl.2010.01.080. Epub 2010 Jan 21.

PubMed ID

20137937 [ View in PubMed

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Abstract

The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the 3-amino-8-azabicyclo[3.2.1]octane found in the CCR5 antagonist maraviroc.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Maraviroc	C-C chemokine receptor type 5	IC 50 (nM)	1.4	N/A	N/A	Details